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Welcome to the Marie Curie Research Training Network in

 Aquaglyceroporin research



 The overall goal of this project is to provide high-level training to early-stage researchers and experienced researchers in integrated analysis of cell physiology by performing interdisciplinary analyses of the role, structure, function and regulation of aquaporins, thereby advancing this field and contribute to structuring the area within Europe.

This Research training network will combine concepts and techniques from molecular cell biology; physiology and systems biology of cell, tissue and animal models; clinical studies; model organisms; protein production, purification and crystallisation; structural biology by atomic force microscopy, electron crystallography and X-ray crystallography; computational biology via molecular dynamics simulation and mathematical modelling; rational molecular design, organic chemistry and combinatorial chemistry.

This project relies on the following main activities:

1. Six joint PhD projects, in which students undergo their entire PhD programme in the project.

2. Four Post-doctoral projects, for 2 years

3. Two scientific meetings per year
4. Joint courses and workshops, which will be a central part of the training, communication, networking and dissemination activities.

This network is centred on four ambitious scientific goals:

        Achieve an understanding of the physiological role of aqua(glycero)porins in order to assess their importance in health and disease and their use as drug targets.

        Achieve a detailed understanding of the mechanisms that control aqua(glycero)porins, to gain new knowledge of control principles and to identify targets to interfere with AQP function, this includes a systems biology approach.

        Fully understand the structural determinants of transport, specificity and regulation of all mammalian aqua(glycero)porins to support rationale drug design and to elucidate the mechanisms of action of novel aquaporin blockers.

        Develop specific AQP blockers, understand their mechanism of action and test their function in different model systems.