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PARTNERS
AMPKIN has five partners with six research groups:
1a. Stefan Hohmann, Göteborg University (coordinator).
The group studies stress responses and homeostatic control systems in yeast. Emphasis has been lately on osmoregulation, where the group has used systems biology approaches to study feedback control of the osmoadaptive systems. Apart from signalling, the group also studies the control of yeast aquaporins and aquaglyceroporins in osmoregulation. The team also has a tradition in studying nutrient responses in yeast.
The group presently consists of about five post-doctoral and ten pre-doctoral scientists. It is part of a number of international and local networks and a driving force in etsblishing systems and quantitative biology. The group has access to excellent facilities to study yeast at the molecular and cell biological level.
Research group Stefan Hohmann, Department of Cell and Molecular Biology, Göteborg University, Box 462, 40530 Göteborg, Sweden
E-mail: hohmann(at)gmm.gu.se
Phone: +46 31 7732595
1b. Dag Hanstorp, Göteborg University
The optical tweezers group at Göteborg University is developing experimental platforms where optical manipulation is combined with advanced imaging techniques and then applied in the field of microbiology. Optical tweezers and laser scalpels are combined with various advance imaging techniques such as confocal and Raman microscopy. Further, lithographic techniques are used to produce microchannel system where cells can be placed and studied under the microscope. In these systems, single cells can be exposed to different environmental conditions and treatments without being removed or exposed to contaminations. Our platforms have, for instance, been used to performed cell array screenings in a study of bacterial viability, to studied molecular diffusion in mutants of E. coli bacteria and in an investigation of the oxygenation cycle in red blood cells.
2. Olaf Wolkenhauer, University of Rostock
Research group Olaf Wolkenhauer, Systems Biology & Bioinformatics Group, University of Rostock, Albert Einstein Str. 21, 18051 Rostock, Germany
E-mail: ow(at)informatik.uni-rostock.de
Tel./Fax: +49 (0)381 498 33 35/36
3. David Carling, MRC, Imperial College London
The Cellular Stress Group is headed by David Carling and is part of the Clinical Sciences Centre, situated on the Hammersmith Hospital Campus in West London. Our group currently consists of 11 post-doctoral fellows and 3 PhD students and there is extensive experience in molecular biology and protein biochemistry. In addition, we have recently developed research involving proteomicstudies. Numerous reagents are available for the study of AMP-activated protein kinase, including transgenic animal models. The Clinical Sciences Centre offers World-class facilities, including transgenics, cell sorting, microarrays, genetics/genomics, microscopy, mass spectrometry and animal and clinical imaging (MRI and PET).
Research group David Carling, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, DuCane Road, London, W12 0NN
Email: dcarling(at)imperial.ac.uk
Tel: 44(0) 208 383 4313, Fax 44(0) 208 383 8306
4. Jens Nielsen, Technical University of Denmark
The group of Jens Nielsen at Center for Microbial Biotechnology focus on yeast and fungal biotechnology, and among the research activities is study of glucose sensing and repression in yeast. The group has studied glucose repression for several years and currently this biological system is used as a paradigm for systems analysis of complex regulatory structures in yeast. The current analysis involves the use of genome-wide transcription analysis using DNA arrays and metabolome analysis using GC-MS and LC-MS. The group has developed different novel bioinformatics techniques for analysis of transcription data, and some of these involve the use of genome scale metabolic models. The group also has developed techiques for analysis of the metabolic fluxes based on 13C-labeled carbon sources. The group is very well equipped for doing state-of the art research in the field of systems biology, i.e. there is access to many highly-instrumented bioreactors that enables running experiments where yeast cells are exposed to well-controlled environmental conditions, several MS systems (both GC-MS and LC-MS) for metabolite analysis, and an Affymetrix system for transcription analysis. The group currently consists of >5 post docs, >15 PhD students and several technicians.
Research group Jens Nielsen, Center for Microbial Biotechnology, Technical University of Denmark, Building 223, DK-2800 Kgs. Lyngby, Denmark
E-mail: jn(at)biocentrum.dtu.dk
Tel: +45 4525 2696
5. Thomas Svensson, Arexis AB Göteborg
Arexis is a privately-owned drug development company with an attractive portfolio of projects, ranging in development from pre-clinical to near commercial stages. Arexis focuses on development of drugs to treat metabolic and inflammatory diseases, such as fat mal-absorption, diabetes, atopic dermatitis and rheumatoid arthritis. These are areas with great unmet medical need and largely unknown disease mechanisms. Arexis has a strong intellectual property and technology platform. The company was founded in 1999, and operates in custom-designed laboratories in Biotech Center in Gothenburg, Sweden.
Research group Thomas Svensson, Director Bioinformatics, Arexis AB, Arvid Wallgrens Backe SE-413 46 Göteborg Sweden
E-mail: thomas.svensson(at)arexis.com
Phone: +46-31 749 11 13, Fax: +46-31 749 11 01
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